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Optimization in drug discovery : in vitro methods / edited by Zhengyin Yan, Gary W. Caldwell.

Contributor(s): Material type: TextTextSeries: Methods in pharmacology and toxicologyPublication details: Totowa, N.J. : Humana Press, c2004.Description: xv, 418 p. : ill. ; 23 cmISBN:
  • 1588293327 (alk. paper)
Subject(s): DDC classification:
  • 615/.19/0072 22
LOC classification:
  • RS407 .O66-2004
NLM classification:
  • QV 771
Online resources:
Contents:
Detection of DNA adducts by 32P-postlabeling analysis / Naomi Suzuki, Padmaja M. Prabhu, and Shinya Shibutani -- Covalent DNA adduct formation mediated by cytochrome P450 / Marie Stiborov�a -- Application of in vitro comet assay for genoto
In vitro identification of UDP-glucuronosyltransferases involved in drug metabolism / Michael H. Court -- In vitro CYP induction in human hepatocytes / Daniel R. Mudra and Andrew Parkinson -- High-throughput screening of human cytochrome P450 in
Isothermal titration calorimetry characterization of drug-binding energetics to blood proteins / Gary W. Caldwell and Zhengyin Yan -- Metabolic stability assessed by liver microsomes and hepatocytes / David C. Ackley, Kevin T. Rockich, and Timot
pKa, solubility and lipophilicity: assessing physicochemical properties of lead compounds / Yushen Guo and Hong Shen -- Use of caco-2 cell monolayers to study drug absorption and metabolism / Ming Hu ... [et al.] -- Absorption screening using th
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Item type Current library Call number Status Date due Barcode
Book Book Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD) Library RS-407-.O66-2004 (Browse shelf(Opens below)) Available P 620

Includes bibliographical references and index.

Detection of DNA adducts by 32P-postlabeling analysis / Naomi Suzuki, Padmaja M. Prabhu, and Shinya Shibutani -- Covalent DNA adduct formation mediated by cytochrome P450 / Marie Stiborov�a -- Application of in vitro comet assay for genoto

In vitro identification of UDP-glucuronosyltransferases involved in drug metabolism / Michael H. Court -- In vitro CYP induction in human hepatocytes / Daniel R. Mudra and Andrew Parkinson -- High-throughput screening of human cytochrome P450 in

Isothermal titration calorimetry characterization of drug-binding energetics to blood proteins / Gary W. Caldwell and Zhengyin Yan -- Metabolic stability assessed by liver microsomes and hepatocytes / David C. Ackley, Kevin T. Rockich, and Timot

pKa, solubility and lipophilicity: assessing physicochemical properties of lead compounds / Yushen Guo and Hong Shen -- Use of caco-2 cell monolayers to study drug absorption and metabolism / Ming Hu ... [et al.] -- Absorption screening using th