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Optimization in drug discovery : in vitro methods / edited by Zhengyin Yan, Gary W. Caldwell. - Totowa, N.J. : Humana Press, c2004. - xv, 418 p. : ill. ; 23 cm. - Methods in pharmacology and toxicology .

Includes bibliographical references and index.

Detection of DNA adducts by 32P-postlabeling analysis / Naomi Suzuki, Padmaja M. Prabhu, and Shinya Shibutani -- Covalent DNA adduct formation mediated by cytochrome P450 / Marie Stiborov�a -- Application of in vitro comet assay for genoto In vitro identification of UDP-glucuronosyltransferases involved in drug metabolism / Michael H. Court -- In vitro CYP induction in human hepatocytes / Daniel R. Mudra and Andrew Parkinson -- High-throughput screening of human cytochrome P450 in Isothermal titration calorimetry characterization of drug-binding energetics to blood proteins / Gary W. Caldwell and Zhengyin Yan -- Metabolic stability assessed by liver microsomes and hepatocytes / David C. Ackley, Kevin T. Rockich, and Timot pKa, solubility and lipophilicity: assessing physicochemical properties of lead compounds / Yushen Guo and Hong Shen -- Use of caco-2 cell monolayers to study drug absorption and metabolism / Ming Hu ... [et al.] -- Absorption screening using th

ISBN: 1588293327 (alk. paper)

LCCN: 2004008395

Subjects--Topical Terms:
Drugs--Testing--Laboratory manuals.
Pharmaceutical chemistry--Laboratory manuals.
Physical biochemistry--Laboratory manuals.
Drug Evaluation, Preclinical--methods.

LC Class. No.: RS407 / .O66-2004

Dewey Class. No.: 615/.19/0072

National Library of Medicine Call No.: QV 771 / O62 2004