| 000 | 02609cam a22004214a 4500 | ||
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| 001 | P 620 | ||
| 005 | 20140212102825.0 | ||
| 008 | 040409s2004 njua b 001 0 eng | ||
| 010 | _a 2004008395 | ||
| 020 | _a1588293327 (alk. paper) | ||
| 035 | _a(DNLM)101213127 | ||
| 040 |
_aDNLM/DLC _cDLC _dDLC |
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| 042 | _apcc | ||
| 050 | 0 | 0 |
_aRS407 _b.O66-2004 |
| 060 | 1 | 0 |
_aQV 771 _bO62 2004 |
| 082 | 0 | 0 |
_a615/.19/0072 _222 |
| 245 | 0 | 0 |
_aOptimization in drug discovery : _bin vitro methods / _cedited by Zhengyin Yan, Gary W. Caldwell. |
| 260 |
_aTotowa, N.J. : _bHumana Press, _cc2004. |
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| 300 |
_axv, 418 p. : _bill. ; _c23 cm. |
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| 440 | 0 | _aMethods in pharmacology and toxicology | |
| 504 | _aIncludes bibliographical references and index. | ||
| 505 | _aDetection of DNA adducts by 32P-postlabeling analysis / Naomi Suzuki, Padmaja M. Prabhu, and Shinya Shibutani -- Covalent DNA adduct formation mediated by cytochrome P450 / Marie Stiborov�a -- Application of in vitro comet assay for genoto | ||
| 505 | _aIn vitro identification of UDP-glucuronosyltransferases involved in drug metabolism / Michael H. Court -- In vitro CYP induction in human hepatocytes / Daniel R. Mudra and Andrew Parkinson -- High-throughput screening of human cytochrome P450 in | ||
| 505 | _aIsothermal titration calorimetry characterization of drug-binding energetics to blood proteins / Gary W. Caldwell and Zhengyin Yan -- Metabolic stability assessed by liver microsomes and hepatocytes / David C. Ackley, Kevin T. Rockich, and Timot | ||
| 505 | _apKa, solubility and lipophilicity: assessing physicochemical properties of lead compounds / Yushen Guo and Hong Shen -- Use of caco-2 cell monolayers to study drug absorption and metabolism / Ming Hu ... [et al.] -- Absorption screening using th | ||
| 650 | 0 |
_aDrugs _xTesting _vLaboratory manuals. |
|
| 650 | 0 |
_aPharmaceutical chemistry _vLaboratory manuals. |
|
| 650 | 0 |
_aPhysical biochemistry _vLaboratory manuals. |
|
| 650 | 1 | 2 |
_aDrug Evaluation, Preclinical _xmethods. |
| 700 | 1 |
_aCaldwell, Gary, _d1953- |
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| 700 | 1 | _aYan, Zhengyin. | |
| 856 | 4 | 1 |
_3Table of contents _uhttp://www.loc.gov/catdir/toc/ecip0417/2004008395.html |
| 856 | 4 | 2 |
_3Publisher description _uhttp://www.loc.gov/catdir/enhancements/fy0825/2004008395-d.html |
| 906 |
_a7 _bcbc _corignew _d1 _eecip _f20 _gy-gencatlg |
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| 925 | 0 |
_aacquire _b1 shelf copy _xpolicy default |
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| 942 | _cBK | ||
| 955 |
_djc02 2004-04-14 to technician _ejc03 2004-04-14 to Dewey _fjc09 2004-09-13; _gjc13 2004-09-22 to BCCD |
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