Statistical issues in drug development /
Senn, Stephen.
Statistical issues in drug development / Stephen Senn. - 2nd ed. - Chichester, England ; Hoboken, NJ : John Wiley & Sons, c2007. - xix, 498 p. : ill. ; 25 cm. - Statistics in practice .
Includes bibliographical references and index.
A brief and superficial history of statistics for drug developers -- Design and interpretation of clinical trials as seen by a statistician -- Probability, Bayes, P-values, tests of hypotheses, and confidence intervals -- The work of the pharmac Meta-analysis -- Cross-over trials -- n-of-1 trials -- Sequential trials -- Dose-finding -- Concerning pharmacokinetics and pharmacodynamics -- Bioequivalence studies -- Safety data, harms, drug monitoring, and pharmaco-epidemiology -- Pharmaco- The measurement of treatment effects -- Demographic subgroups : representation and analysis -- Multiplicity -- Intention to treat, missing data and related matters -- One-sided and two-sided tests and other issues to do with significance and P-v
0470018771 (cloth : alk. paper) 9780470018774 (cloth : alk. paper)
2007045553
101319993 DNLM
Drug development--Statistical methods.
Clinical Trials as Topic.
Drug Design.
Statistics as Topic--methods.
RM301.25 / .S46-2007
615/.190727
Statistical issues in drug development / Stephen Senn. - 2nd ed. - Chichester, England ; Hoboken, NJ : John Wiley & Sons, c2007. - xix, 498 p. : ill. ; 25 cm. - Statistics in practice .
Includes bibliographical references and index.
A brief and superficial history of statistics for drug developers -- Design and interpretation of clinical trials as seen by a statistician -- Probability, Bayes, P-values, tests of hypotheses, and confidence intervals -- The work of the pharmac Meta-analysis -- Cross-over trials -- n-of-1 trials -- Sequential trials -- Dose-finding -- Concerning pharmacokinetics and pharmacodynamics -- Bioequivalence studies -- Safety data, harms, drug monitoring, and pharmaco-epidemiology -- Pharmaco- The measurement of treatment effects -- Demographic subgroups : representation and analysis -- Multiplicity -- Intention to treat, missing data and related matters -- One-sided and two-sided tests and other issues to do with significance and P-v
0470018771 (cloth : alk. paper) 9780470018774 (cloth : alk. paper)
2007045553
101319993 DNLM
Drug development--Statistical methods.
Clinical Trials as Topic.
Drug Design.
Statistics as Topic--methods.
RM301.25 / .S46-2007
615/.190727